Pemphigoid gestationis in a female with progressive facial hemiatrophy: microchimerism as a speculative shared background is disputable.
نویسندگان
چکیده
The commonest source of naturally acquired microchimerism, i.e. small numbers of foreign cells within the organism, is two-way mother-fetus transplacental trafficking during pregnancy. Here, the first report on coexistence of pregnancy-associated pemphigoid gestationis (PG) and progressive facial hemiatrophy, a form of "en coup de sabre" morphea, is presented. HE histopathology (eosinophil-rich subepidermal infiltration, inverted teardrop sign), direct immunofluorescence (linear IgG1, but not IgG4, deposits along the dermal-epidermal junction) and ELISA (elevated levels of serum and blister fluid IgG autoantibodies to BP180) corroborated the PG diagnosis. Microchimerism as a speculative shared background of those two rare autoimmune diseases is disputable.
منابع مشابه
Case report of progressive facial hemiatrophy
Introduction: Progressive facial hemiatrophy (Parry-Romberg syndrome) is a rare disease ‎always with neurological symptoms such as migraine and epilepsy. Parry-Romberg syndrome ‎is determined with progressive slow hemiatrophy of skin and soft tissue structures in face and ‎frequently in left face. Disease is more common in females. The objective of this paper is to ‎present a ca...
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عنوان ژورنال:
- Polish journal of pathology : official journal of the Polish Society of Pathologists
دوره 63 1 شماره
صفحات -
تاریخ انتشار 2012